April 6, 2023Open Access

A senescence-based prognostic gene signature for colorectal cancer and identification of the role of SPP1-positive macrophages in tumor senescence

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Abstract

Our study presents a novel model based on senescence-related genes that can identify CRC patients with a poor prognosis and an immunosuppressive tumor microenvironment. SPP1+ macrophages may correlate with cell senescence leading to poor prognosis.

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Yu et al. (Thu,) studied this question.

synapsesocial.com/papers/69dff6591827a1d0b125586a https://doi.org/https://doi.org/10.3389/fimmu.2023.1175490

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