Diffusion Magnetic Resonance Imaging of Cortical Microstructure Differs in Nonmanifest and Manifest Genetic Parkinson's Disease

Key Points

• The research investigates the role of cortical diffusivity metrics in identifying genetic Parkinson's disease stages.
• Used diffusion magnetic resonance imaging (MRI) to assess cortical changes.
• Compared cortical metrics between manifest and nonmanifest genetic Parkinson's disease cases.
• Analyzed diffusivity metrics as potential neurodegenerative markers.
• Cortical diffusivity metrics show significant differences between manifest and nonmanifest cases.
• Findings support the use of these metrics as indicators of cortical architectural changes in genetic Parkinson's disease.