Single Institution Experience Using Circulating Tumor DNA to Monitor Recurrence in Rectal Cancer

Key Points

• To explore the role of circulating tumor DNA in monitoring rectal cancer recurrence and its potential impact on management.
• Monitored circulating tumor DNA levels in patients with rectal cancer undergoing watch and wait or surgery.
• Compared early identification of recurrences through circulating tumor DNA to traditional methods.
• Analyzed the implications of positive circulating tumor DNA on treatment decisions.
• Positive circulating tumor DNA indicated a higher likelihood of distant metastases rather than local recurrence.
• Earlier identification of recurrences was achieved compared to traditional monitoring methods.
• Findings suggest potential changes in management strategies, particularly regarding salvage surgery.