Somatic copy number variations as long-term genomic biomarkers of ionizing radiation exposure in individuals accidentally exposed to Cesium-137 during the Goiânia radiological accident

Key Points

• The study aims to investigate somatic copy number variations as long-term genomic biomarkers of radiation exposure.
• Analyzed somatic CNVs in individuals exposed to Cesium-137 during the Goiânia accident.
• Utilized CNV profiling techniques to assess genomic signatures.
• Evaluated the persistence of CNVs decades after exposure.
• Somatic CNVs remained quantifiable biomarkers of ionizing radiation exposure long after the event.
• CNV profiling was identified as a potential tool for retrospective biodosimetry.
• Findings support CNV use in long-term health monitoring and radiological risk assessment frameworks.