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April 17, 2026Open Access

JAK2 and NOTCH2 in gastric cancer – NOTCH2 is an independent prognosticator of poor patient outcome

Key Points

The research aims to investigate the significance of JAK2 and NOTCH2 in gastric carcinoma and their impact on patient survival.
Analyzed 447 resection specimens of gastric adenocarcinomas using immunohistochemistry.
Generated a Histoscore for expression data.
Correlated expression levels with patient survival and clinicopathological characteristics.
NOTCH2 was identified as an independent prognosticator of poor survival outcomes.
Patients with high NOTCH2 expression had a median survival of 7.2 months compared to 16.7 months for low expression (p < 0.001).
JAK2 expression showed no correlation with NOTCH2, but lower JAK2 levels were associated with poorer tumor-specific survival.

Abstract

Abstract Gastric carcinomas occasionally harbor genetic alterations of JAK2 and NOTCH2 . In this study we investigated the tumor biological significance of JAK2 and NOTCH2 in gastric carcinoma. The expression of JAK2 and NOTCH2 was studied by immunohistochemistry using whole mount tissue sections obtained from 447 resection specimens of gastric adenocarcinomas. A Histoscore was generated and expression data were correlated with patient survival and clinicopathological patient characteristics. Both JAK2 and NOTCH2 were heterogeneously expressed intratumorally in gastric cancer. The number of cases showing high expression of JAK2 (5.4%) and NOTCH2 (3.4%) was low matching with genetic data retrieved from cBioPortal. NOTCH2 was an independent prognosticator of poor outcome (tumor-specific survival: 16.7 ± 1.5 months in the NOTCH2 “low” vs. 7.2 ± 0.7 months in the NOTCH2 “high” cohort; p = < 0.001). To the contrary, patients with little or no expression of JAK2 showed a worse tumor-specific survival (15.4 ± 1.3 months in the JAK2 “low” group vs. 19.5 ± 13.1 months in the JAK2 “high” group; p = 0.041). No correlation was found between expression of JAK2 and NOTCH2. JAK2 and NOTCH2 are differently expressed in gastric adenocarcinoms and of putative tumor biological significance. Particularly NOTCH2 turned out to be an independent prognosticator of poor patient outcome.

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