Drug-induced peripheral neuropathy (DIPN) is a multifocal impairment of the peripheral nerves that occurs as an adverse reaction to certain classes of medications. Modern pathology, associated with considerable morbidity and mortality, imposes strict requirements regarding the efficacy and safety of the therapies used. Many essential medications, including antitumor, anti-infective, cardiovascular, and immunosuppressive agents, can induce peripheral neuropathy as an adverse reaction, significantly affecting patients’ quality of life and limiting therapeutic options. The aim of this analysis is to highlight the neurotoxicity mechanisms involved in drug-induced peripheral neuropathy (DIPN) by analyzing the main groups of medications frequently associated with the development of peripheral neuropathy, as well as to provide a concise overview of the clinical manifestations, early diagnostic methods and treatment. In conclusion, although the clinical manifestations and, to some extent, the neurotoxicity mechanisms have been described for numerous classes of drugs, the lack of curative treatments underscores the importance of prevention and early detection, as well as the need for a multidisciplinary and personalized therapeutic approach focused on symptom control and improving quality of life.
Stratu et al. (Thu,) studied this question.