Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures

Key Points

• This research aims to evaluate the effectiveness of combining tobramycin and vancomycin in preventing surgical site infections in tibial fractures.
• Applied tobramycin and vancomycin powders topically during surgical closure.
• Compared to a control group receiving only vancomycin powder.
• Focused on patients with periarticular tibial fractures.
• Combination therapy showed a reduction in deep surgical site infections compared to vancomycin alone.
• Indicated that tobramycin enhances antibacterial efficacy in this surgical context.