Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Key Points

• The study examines compliance with treatment protocols for Wilms tumour in children, particularly in advanced stages.
• Analyzed adherence to protocol recommendations in two consecutive studies.
• Examined outcomes based on centre size and treatment protocols.
• Conducted a review of central pathology for consistency in diagnoses.
• Lower stage tumours showed high adherence to treatment protocols.
• Advanced disease exhibited significant variation in adherence to guidelines.
• No link was found between centre size and survival outcomes.