Our findings indicate that DKD patients exhibit distinct patterns of brain activity compared to non-DKD patients, with the putamen potentially acting as a key neural target in the progression of CKD. These functional alterations correlate closely with systemic status, suggesting a significant role in the pathogenesis of neural impairment. Our results may enhance the understanding of neural functional alterations and the underlying mechanisms in non-DKD and DKD patients.
Lei et al. (Wed,) studied this question.