A multifunctional lipid-lowering nanotherapeutic alleviates lipid deposition associated microglial dysfunction

Key Points

• This research aims to explore a nanotherapeutic approach to reduce lipid-related dysfunction in microglia.
• Utilized a multifunctional nanotherapeutic integrating lipid adsorption and berberine loading.
• Assessed oxidative stress levels in microglia pre- and post-treatment.
• Compared mitochondrial function in microglia with and without the nanotherapeutic.
• Demonstrated decreased oxidative stress in treated microglia.
• Showed reduction in mitochondrial injury associated with lipid overload.
• Highlighted improved microglial viability in lipid-laden environments after treatment.