The Phase‐Amplitude Coupling Induced by Drug Cues in Individuals With Methamphetamine Use Disorder During Withdrawal

Key Points

• This research aims to evaluate how drug-related cues influence craving during withdrawal in individuals with methamphetamine use disorder.
• Analyzed the effects of drug cues on craving intensity.
• Investigated phase-amplitude coupling (PAC) and other neural interactions.
• Assessed participants during withdrawal to measure neural responses.
• Utilized predictive biomarkers for craving severity evaluation.
• Drug cues significantly increased craving levels.
• PAC and other biomarkers correlated with craving severity.
• Findings highlight the role of prefrontal regulation in craving responses.