Polygenic risk scores and lifestyle factors predicting new onset of type 2 diabetes in the Japanese general population

Key Points

• To investigate how polygenic risk scores and lifestyle habits predict the onset of type 2 diabetes in the Japanese population.
• Analyzed polygenic risk scores (PRS) in the Japanese general population
• Assessed lifestyle factors such as diet and physical activity
• Estimated diabetes onset in relation to PRS and lifestyle habits
• Found that PRS predicts diabetes risk independently of other factors
• Highlighted the role of healthy lifestyle in reducing diabetes risk, even for genetically susceptible individuals
• Supports the use of PRS for personalized diabetes risk assessments