Does carrying the minor C allele of the BNP genetic variant rs198389 reduce the risk of hypertension, new-onset left ventricular systolic dysfunction, and hospitalization for major adverse cardiovascular events in patients with Stage A and B heart failure?
Patients with Stage A and B heart failure
Carriers of the minor C allele of the BNP genetic variant rs198389
Hypertension, new-onset left ventricular systolic dysfunction, and hospitalization for major adverse cardiovascular eventshard clinical
The minor C allele of the BNP genetic variant rs198389 is associated with higher BNP levels and a decreased risk of adverse cardiovascular outcomes in patients with Stage A and B heart failure.
B-type natriuretic peptide (BNP) possesses blood-pressure-lowering, antifibrotic, and aldosterone-suppressing properties. In Stage A and B heart failure, the carriers of the minor C allele of the BNP genetic variant rs198389 have higher circulating levels of BNP and are at decreased risk of hypertension, new-onset left ventricular systolic dysfunction, and hospitalization for major adverse cardiovascular events. Future studies are warranted to investigate the role of BNP genetic testing and BNP-based therapy in the prevention of heart failure.
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Valentina Cannone
University of Verona
Mark Ledwidge
Heart Failure & Transplant
Chris Watson
Heart Failure & Transplant
JACC Basic to Translational Science
Mayo Clinic
University College Dublin
Queen's University Belfast
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Cannone et al. (Tue,) studied this question.
synapsesocial.com/papers/69e6b9833ca116d60ece4bfb — DOI: https://doi.org/10.1016/j.jacbts.2021.05.001
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