Background Sepsis‐associated liver injury (SALI) is a poor prognostic manifestation in intensive care unit (ICU) patients. Therefore, early prediction of the patients who will progress to SALI is very critical. This study aimed to investigate possible demographic, clinical, and laboratory features that may early predict SALI in patients with sepsis in the ICU. Methods The study was conducted on adult patients with sepsis admitted to the ICU of a tertiary hospital between January 2022 and December 2022. Demographic, clinical, and laboratory data within the initial 24 h of admission to the ICU were recorded. These data were compared between the patients with and without SALI. Results A total of 264 eligible patients (median age 73 years, 56.4% male) with sepsis were included in the study, 39 (14.8%) of whom had SALI. Prothrombin time, total bilirubin, alkaline phosphatase, and heart rate within the initial 24 h of admission to the ICU were statistically significantly higher in the patients with SALI compared to the patients without SALI ( p = 0.023, p = 0.008, p = 0.036, and p = 0.006, respectively), while hematocrit and bicarbonate levels were lower ( p = 0.034 and p = 0.049, respectively). Conclusions Elevated prothrombin time, alkaline phosphatase, heart rate, and total bilirubin and low bicarbonate and hematocrit levels in the initial 24 h of the ICU admission are associated with SALI in the adult patients with sepsis.
Kılıç et al. (Thu,) studied this question.