Transcriptome Analysis and Histological Validation Identified the HO ‐1‐ u ‐1 Cell Line as a Model for Perineural Invasion in Oral Squamous Cell Carcinoma

Key Points

• To identify pathways driving perineural invasion in oral squamous cell carcinoma (OSCC) and validate a cell line model.
• Conducted transcriptome analysis of specific OSCC cell lines
• Utilized histological validation techniques
• Identified HO-1-u-1 cell line for further studies
• HO-1-u-1 exhibits strong neurotropic properties
• It serves as a valuable xenograft model for studying PNI in OSCC
• Distinct pathways implicated in perineural invasion of different OSCC types