What question did this study set out to answer?

This research aims to evaluate the relationship between gestational diabetes mellitus and the risk of chronic kidney disease in mothers.

April 24, 2026Endocrinology Diabetes & Metabolism1 citationsOpen Access

View Full Paper

Gestational Diabetes and Long‐Term Risk of Maternal Kidney Disease: Systematic Review and Meta‐Analysis of Population Base Cohort Studies

MBMansour BahardoustIran University of Medical Sciences ERElham RahimpourShiraz University of Medical Sciences SSS. ShokohyarMGH Institute of Health Professions

Key Points

This research aims to evaluate the relationship between gestational diabetes mellitus and the risk of chronic kidney disease in mothers.
Conducted a systematic review of studies from databases like MEDLINE/PubMed and EMBASE up to August 2025.
Assessed heterogeneity of studies using Cochrane's Q and I2 tests.
Performed meta-regression to identify factors contributing to study variability.
Found a significant association between gestational diabetes and increased risk of chronic kidney disease (HR: 2.19).
The association remained significant even when adjusting for confounding variables (HR: 2.47).
No significant link was found between gestational diabetes and acute kidney injury in a limited number of studies.

Abstract

ABSTRACT Background Gestational diabetes mellitus (GDM) may increase the risk of maternal chronic kidney disease (CKD). The association of GDM with maternal CKD has been heterogeneous across studies, and this association remains controversial. The aim of this systematic review was to investigate the association of GDM with the risk of maternal CKD. Methods MEDLINE/PubMed, EMBASE, Scopus and Web of Science were searched, with no time limit, up to 25 August 2025 by two independent investigators to identify studies that had assessed the association of GDM with maternal risk of CKD. Heterogeneity between studies was assessed using Cochrane's Q and I2 tests. Meta‐regression was performed to identify factors associated with heterogeneity. Results Eleven cohort studies involving 21,313,434 participants (1,530,599 (7.2%) GDM) were included. Pooled estimates from eleven studies showed that GDM was significantly associated with an increased risk of maternal CKD (HR: 2.19; 95% CI: 1.7, 2.68; p: 0.001, I 2 :92.2%). Further analyses restricted to studies adjusting for key confounders (HR: 2.47; 95% CI: 1.87, 3.08; p: 0.001, I2:24.2%) also showed a significant association. While pooled estimates from three studies did not show a significant association between GDM and an increased risk of AKI (HR: 1.1; 95% CI: 0.94, 1.26). Subgroup analyses showed that GDM was significantly associated with an increased risk of maternal CKD in both DM + (HR: 6.24) and DM ‐ (HR: 1.4). Conclusion Gestational diabetes mellitus (GDM) with and without DM was significantly associated with an increased risk of maternal CKD. GDM with DM had a synergistic effect on maternal CKD risk. Although GDM was not significantly associated with increased AKI, only three studies were included in the AKI analysis, which may have affected these results by random error and therefore lack sufficient power and evidence to draw conclusions.

KI fragen

Bookmark

View Full Paper

Cite This Study

Bahardoust et al. (Wed,) studied this question.

synapsesocial.com/papers/69eb09ff553a5433e34b4329 https://doi.org/https://doi.org/10.1002/edm2.70208

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

KI fragen

Bookmark

View Full Paper