Association Between Cardiovascular Polygenic Risk and White Matter Hyperintensities: An Observational Study From the UK Biobank
Key Points
This research aims to explore how genetic factors influence the relationship between cardiovascular risk and white matter hyperintensities.
Observational study using data from the UK Biobank
Analysis of cardiovascular polygenic risk scores
Assessment of white matter hyperintensity burden
Found a clear association between higher polygenic risk and increased white matter hyperintensity burden
Supports the role of genetic background in cardiovascular disease risk
Abstract
The association between WMH burden and cardiovascular-related disease risk is influenced by genetic background, supporting precision risk stratification and prevention in clinical practice.