Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index

Key Points

• This research aims to explore the connection between serum creatinine clearance and cognitive function, focusing on the role of systemic inflammation.
• Analyzed cognitive performance using CERAD, DSST, and Z-GCP tests in older adults.
• Evaluated the association between serum creatinine clearance and cognitive outcomes.
• Assessed the mediating effect of systemic inflammatory response index on these associations.
• Higher serum creatinine clearance correlates with better cognitive performance in older adults.
• Systemic inflammation, represented by SIRI, partially mediates the effect of creatinine levels on cognitive outcomes.