Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three‐Component Reaction for the Synthesis of β‐Amino‐α‐hydroxyesters with Quaternary Stereocenters

In one huge stride: The single-step construction of polyfunctionalized compounds with a quaternary stereocenter is possible through a highly diastereoselective multicomponent reaction of phenyldiazoacetates, alcohols, and imines (see scheme). The use of N- (tert-butylsulfinyl) imines as the imine component provides ready access to β-amino-α-hydroxyesters of high optical purity. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2007/z604389ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.