Exposure to electronic cigarette aerosols triggers alterations in genomic DNA methylation that impacts cancer pathways in mice

Key Points

• This research investigates how electronic cigarette aerosols modify DNA methylation and its implications for cancer pathways in mice.
• Sub-chronic exposure to electronic cigarette aerosols in two strains of adult male mice
• Analysis of genomic DNA methylation changes
• Investigation of strain-specific response differences
• Significant alterations in genomic DNA methylation linked to cancer pathways observed
• Differences in responses between the two strains of mice noted
• Compelling evidence of adverse effects from e-cigarette exposure found