Current Insights into Plausible Mechanisms of Chromium (VI) Neurotoxicity in the Brain and Future Perspectives.

Key Points

• This research explores the mechanisms behind chromium VI neurotoxicity and its implications for human health. It aims to define harmful exposure levels and potential treatments.
• Reviewed animal studies on oxidative stress mechanisms of Cr (VI).
• Analyzed human cohort studies linking Cr (VI) to neurodegenerative and neurobehavioral disorders.
• Confirmed oxidative stress as a key mechanism in Cr (VI)-induced neurotoxicity.
• Identified Cr (VI) as a significant environmental risk for neurodegenerative diseases.
• Highlighted the need for future research on antioxidant therapies to mitigate neurotoxic effects.