Linking Mitochondrial Dysfunction to the Immune Microenvironment in HFpEF: An Integrated Bioinformatics and Experimental Approach

Key Points

• This research aims to identify the relationship between mitochondrial dysfunction and immune dysregulation in HFpEF.
• Conducted integrated bioinformatics analysis
• Identified key mitochondrial genes CHCHD1 and EFHD1
• Utilized experimental approaches to validate findings
• CHCHD1 and EFHD1 were confirmed as crucial mitochondrial genes in HFpEF
• Revelations provide insights into molecular mechanisms of immune dysregulation
• Identified potential therapeutic targets for intervention