Do PVCs on a resting ECG and increased resting heart rate predict all-cause and cardiovascular mortality?
The presence of PVCs and an increased resting heart rate independently and synergistically predict increased all-cause and cardiovascular mortality, possibly reflecting an underlying hyperadrenergic state.
PVCs on a resting ECG are a significant and independent predictor of all-cause and cardiovascular mortality. Increased heart rate predicts mortality in patients with and without PVCs and the combination dramatically increases mortality. These findings together with the demonstrated independent association of heart rate with PVCs suggest that a hyperadrenergic state is present in patients with PVCs and that it likely contributes to their adverse prognosis.
Engel et al. (Sun,) studied this question.
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