Rethinking gastroenteropancreatic neuroendocrine neoplasms: A perspective on cellular origins, molecular mechanisms, and combination therapies

Key Points

• The article aims to provide insights on the origins, underlying processes, and potential treatment strategies for gastroenteropancreatic neuroendocrine neoplasms.
• Review of existing literature on cellular origins and molecular mechanisms of neuroendocrine neoplasms.
• Analysis of current and emerging combination therapies for treatment.
• Discussion of clinical implications and future research directions.
• Highlights the diverse cellular origins and biological heterogeneity of gastroenteropancreatic neuroendocrine neoplasms.
• Discusses promising combination therapies that may improve patient outcomes over single-agent treatments.