Do levels of sTNF-RII correlate with short-term prognosis in patients with congestive heart failure?
Elevated sTNF-RII levels are independently associated with poor short-term prognosis in patients with severe congestive heart failure.
Measurement of sTNF-Rs, in addition to antigenic and bioactive TNF-alpha, is essential for evaluation of the activation of this cytokine in CHF. Both sTNF-Rs increase in preterminal patients with severe CHF and might inhibit the in vitro cytotoxicity of TNF-alpha. Antigenic TNF-alpha also increases in severe CHF. The increased levels of sTNF-RII independently correlate with poor short-term prognosis.
Ferrari et al. (Fri,) studied this question.
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