Unraveling the Natural History of Atopic Dermatitis: Prospective Disease Trajectories and Longitudinal IgE Sensitization from Birth to Adolescence

Key Points

• The aim is to investigate the long-term trajectories of atopic dermatitis and its association with IgE sensitization from birth to adolescence.
• Conducted a prospective analysis of physician-diagnosed atopic dermatitis.
• Tracked disease trajectories over time, focusing on allergic comorbidity and IgE sensitization patterns.
• Identified distinct long-term trajectories of atopic dermatitis with varying allergic complications.
• Found that persistent atopic dermatitis correlates with familial predisposition and increased sensitization to food and environmental allergens.