Structure-Based Optimization of Triazole-Linked Sesamol Conjugates as Antifungal Agents Targeting CYP51 in Candida albicans

Key Points

• To explore triazole-linked sesamol conjugates as novel antifungal agents against Candida albicans by targeting CYP51.
• Conducted structure-based optimization of sesamol derivatives.
• Assessed antifungal activity against Candida albicans.
• Evaluated the binding affinity to CYP51.
• Identified optimal triazole-linked sesamol conjugates with significant antifungal activity.
• Demonstrated effective targeting of CYP51 in Candida albicans.