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Immunological and prognostic impact of NRF2 in high grade serous ovarian cancer. | Synapse

May 1, 2026

Immunological and prognostic impact of NRF2 in high grade serous ovarian cancer.

Key Points

This research aims to classify high grade serous ovarian cancer based on NRF2 levels and explore its prognostic significance
Evaluated immune-activated markers such as CD3E and CD80 in tumors
Classified high grade serous ovarian cancer (HGSOC) based on NRF2 levels
Suggested immunohistochemical labeling and genomic evaluation of NRF2 and immune markers
Tumors with higher NRF2 levels exhibit better prognosis
Identification of new biomarkers linked to NRF2
Improved classification and prognosis of HGSOC suggested through IHC-labeling

Abstract

tumors enriched with immune-activated markers such as CD3E and CD80 exhibit a better prognosis. This study is the first that shows classification of HGSOC based on NRF2 levels, highlights new biomarkers, and suggests IHC-labeling and genomic evaluation of NRF2 and immune markers for better prognosis.

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Cite This Study

Hamad et al. (Tue,) studied this question.

synapsesocial.com/papers/69f44325967e944ac55668d2 https://doi.org/https://doi.org/10.1038/s41435-026-00400-7

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