CMCI (Coherence Measurement and Characterization Index) v1.0 is a principled framework for quantifying structural coherence in volumetric data. The framework constructs a composite score from four components, each targeting a structurally independent property: Stability, Organization, Continuity, and Transition Economy. Components are combined via geometric mean, which prevents any single component from dominating and preserves multiplicative balance. The framework is built to be domain-agnostic. It applies to fluorescence microscopy volumes, cosmological density fields, and any other volumetric signal where structural coherence — internal self-consistency across scales and positions — is a meaningful property. Validation in this v1.0 release uses zebrafish brain fluorescence microscopy volumes (Olfactory Bulb and Optic Tectum, 9 slices each at uniform Z-intervals, per-slice min-max normalization). This document is the technical reference for CMCI v1.0 and serves as the methodological foundation for the multiscale transversal extension introduced in companion work (Manuscript A, in preparation for bioRxiv). Keywords: structural coherence, volumetric data, multiscale analysis, biological imaging, methodology.
Christian St-Louis (Wed,) studied this question.
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