Determination of frequency of spontaneous resistance for gepotidacin and levofloxacin against a collection of gram-positive and gram-negative organisms.

Key Points

• This research aims to determine the frequency of spontaneous resistance to gepotidacin and levofloxacin in different bacterial organisms.
• Identified mutations in repressor and activator genes affecting efflux pumps in Gram-negative isolates.
• Analyzed susceptibility patterns of various gram-positive and gram-negative bacterial collections.
• Reduced susceptibility mutations linked to efflux pump mechanisms were observed in Gram-negative isolates.
• Further exploration needed on the clinical impacts of these resistance findings.