Cascade Cell-Assisted Enhanced Fluorescence Strategy for Highly Sensitive Detection of Lung Adenocarcinoma Cells in Whole Blood.

Key Points

• The aim is to develop a highly sensitive method for detecting lung adenocarcinoma cells in whole blood.
• Utilized a cascade cell-assisted enhanced fluorescence strategy for detection.
• Designed modular expansion for customization to detect other tumor circulating tumor cells (CTCs).
• Achieved detection sensitivity of <0.05 with an AUC of 0.728.
• Demonstrated significant potential for diagnostics in lung adenocarcinoma.