Objective: To investigate the prevalence, antimicrobial resistance and genetic diversity of Staphylococcus ( S. ) aureus among healthy young adults of 18 to 25 years in Ho Chi Minh City, Vietnam. Methods: A cross-sectional, descriptive study was conducted between December 2023 and December 2024. Nasal swabs were processed for S. aureus isolation, antibiotic susceptibility testing, and PCR-based detection of spa, pvl , and mecA genes. Genetic similarity was assessed using the unweighted pair group method with arithmetic mean cluster analysis. Statistical significance was determined by Chi-square test. Results: In this cross-sectional study of 428 students, the S. aureus carriage rate was 33.9%. Methicillin-resistant S. aureus (MRSA) prevalence was 54.5% (79/145). 10%-17% of MRSA isolates exhibited resistance to three to ten antibiotics, with two strains demonstrating resistance to 11 and 12 drugs, respectively. The pvl gene was detected in 5.8% of isolates. 55.17% S. aureus strains belonged to ten distinct spa types with 300-bp amplicons. Conclusions: These findings provide valuable insights into S. aureus carriage patterns among youth in Ho Chi Minh City, informing public health strategies for prevention and treatment.
Nguyen et al. (Wed,) studied this question.