Transcriptional transactivation turns human iPSC-derived macrophages into an adenovirus-producing cell state

Key Points

• To investigate the effects of transcriptional transactivation on iPSC-derived macrophages and their role in viral reactivation.
• Utilized human iPSC-derived macrophages
• Induced transcriptional transactivation
• Monitored dormant virus reactivation
• Analyzed epigenetic signals
• Transcriptional transactivation successfully converted macrophages into adenovirus-producing cells
• Dormant viruses were reactivated
• Macrophages were shown to serve as reservoirs for HIV and herpesvirus