BACKGROUND: Multiple myeloma (MM) is an incurable malignancy, marked by treatment resistance and frequent relapses, posing ongoing challenges to patients' long-term management. Herein, we have examined tRNA-derived small RNA fragments (3'U-tRFs), generated from precursor tRNAs, to identify MM-related 3'U-tRFs in ameliorating MM precision prognostics. METHODS: levels were quantified in our MM screening cohort (n = 136 patients) by RT-qPCR. Kaplan-Meier and Cox proportional regression analyses were performed, using disease progression and patients' mortality as clinical endpoints. Internal validation was conducted by bootstrap Cox regression while clinical benefit on patients' prognosis was assessed by decision curve analysis (DCA). RESULTS: -fitted multivariate models demonstrated superior risk-stratification of the patients for treatment response and prognosis. CONCLUSIONS: as a strong independent predictor of poor first-line chemotherapy outcomes and MM progression, providing refined stratification of patient risk.
Soureas et al. (Mon,) studied this question.