Microorganisms - such as bacteria, fungi, and archaea - colonize the bodies of diverse hosts, forming a dynamic combination known as the microbiota and playing essential roles in host health and disease. In this dissertation, I utilized multi-omics approaches, including the analysis of gut microbiome (i.e., bacterial) and mycobiome (i.e., fungal) data, and targeted metabolomics to systematically investigate the key interactions between the gut microbial communities and their hosts. The focus of the studies includes investigating the biotransformation potential of the gut microbiota, the analysis of gut microbiome and mycobiome dynamics in critical illness, and the assessment of the effects of Candida albicans lipase on the gut microbiome.
Lu Zhang (Thu,) studied this question.