What question did this study set out to answer?

To explore the potential of stereoreversed C–O activation for synthesizing all-carbon tetrasubstituted Z-alkenes.

May 7, 2026Journal of the American Chemical Society3 citations

Stereoreversed C–O Activation Unlocks All-Carbon Tetrasubstituted Z -Alkene Synthesis

KCKaixin ChenState Key Laboratory of Chemical Engineering JPJiali PengKarlsruhe Institute of Technology JLJie LinState Key Laboratory of Chemical Engineering

Key Points

To explore the potential of stereoreversed C–O activation for synthesizing all-carbon tetrasubstituted Z-alkenes.
Investigation of C–O activation techniques
Synthesis of Z-alkenes with high stereocontrol
Assessment of yield in drug-related molecular synthesis.
Achieved high-yield synthesis of tetrasubstituted Z-alkenes
Showed effective stereocontrol during synthesis
Indicated promising applications in drug-discovery and medicinal chemistry.

Abstract

-alkenes. Notably, the concise synthesis of drug molecules with high yield and stereocontrol should highlight the potential applications of this technology to the drug-discovery setting in medicinal chemistry.

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