Study on Preparation and Pharmacokinetics of Gentiopicroside Sustained Release Preparation

Key Points

• This research aims to evaluate the preparation and pharmacokinetics of gentiopicroside sustained release formulations.
• Developed two sustained-release formulations of gentiopicroside (GPS-MRT and GPS-MPOP).
• Compared pharmacokinetics and bioavailability of these formulations with reference preparations.
• GPS-MRT had a relative bioavailability of 103.24% and GPS-MPOP had 116.47%.
• Both formulations prolonged drug release and reduced plasma concentration fluctuations.