What question did this study set out to answer?

To explore the effectiveness of denosumab as a non-surgical treatment for mandibular central giant cell granuloma.

May 7, 2026British Journal of Oral and Maxillofacial Surgery0 citationsOpen Access

Non-Surgical Management of Mandibular Central Giant Cell Granuloma Using Denosumab

SPShivanjali PandyaMid Essex Hospital Services NHS Trust MSMegan SamuelBroomfield Hospital JTJanavikulum ThiruchelvamBroomfield Hospital

Key Points

To explore the effectiveness of denosumab as a non-surgical treatment for mandibular central giant cell granuloma.
The case involves a 22-year-old patient with a confirmed mandibular central giant cell granuloma.
Denosumab was administered non-surgically as a treatment option.
Follow-up imaging was conducted to assess lesion stabilization and maturation.
Follow-up imaging showed significant stabilization of the lesion after denosumab treatment.
Radiographic maturation of the mandibular central giant cell granuloma was observed.

Abstract

The typical management of central giant cell granuloma (CGCG) of the jaws involves curettage or resection; however, medical therapies such as denosumab have emerged as potential alternatives in selected cases.We present a case of a 22-year-old patient presenting with a right mandibular expansile lesion.Imaging and biopsy confirmed mandibular CGCG.The patient was managed non-surgically with denosumab, and follow-up imaging demonstrated lesion stabilisation and radiographic maturation.Denosumab may represent an alternative to surgery when operative management carries significant morbidity.

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