VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy

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Abstract

mice inhibited the VEGF:Flt-1 interaction, promoted angiogenesis, and improved muscle function. These studies suggest a potential therapeutic benefit of Flt-1 inhibition for patients with Duchenne muscular dystrophy.

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Bosco et al. (Tue,) studied this question.

synapsesocial.com/papers/69fd2698c105307ccb5094d3 https://doi.org/https://doi.org/10.1016/j.omtm.2021.03.013

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1Pharmacokinetics of Monoclonal Antibodies2017 · 774 citations
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2012 · 63 citations