Abstract Background: Among these, peripheral arterial disease (PAD) and diabetic peripheral neuropathy (DPN) stand out to display significant clinical impact. It is worth mentioning that chronic hyperglycemia is considered to be the major aggravating factor for both DPN and PAD. Objective: To test the relation between peripheral neuropathy and peripheral artery disease and to assess the impact of CGRP on peripheral artery disease in patients with type 2 diabetes mellitus. Materials and Methods: A case–control study which involved 200 diabetic males and females was divided into two groups: Group 1 (94) that includes diabetic patients with peripheral neuropathy (DPN) and Group 2 (106), as control group, that includes diabetic patients without DPN based on electrodiagnosis. There are raged between 30 and 60 years old. Anthropometric measurements including body weight and height, the Doppler study was used to test the lower limbs’ arteries and PAD was diagnosed based on Jerker’s criteria. CGPR serum level was measured by using an enzyme linked immunosorbent assay (ELISA) kit with a detection range of 2–600 ng/L. Results: This study revealed a highly significant increase in glycosylated hemoglobin, while CGRP showed a significant decrease between the study groups. In addition to that PAD showed a significant increase in distribution in the study group than control group. Regarding electrophysiological parameters, changes showed a significant upsurge in latency for motor and sensory nerves and a significant reduction in conduction velocity and amplitude for sensory and motor nerves in addition to a significant prolongation of F wave latency for almost all tested nerves of the study group. The receiver operating curve was used to calculate the cutoff value of CGPR serum level for diagnosing PAD and showed no significant accuracy of 52% with low sensitivity and specificity. There were no significant differences regarding most of the other tested parameters. Conclusion: This study revealed an increased rate of PAD in patients with DPN with no significant relation between CGPR level and PAD and, subsequently, no role in diagnosing or predicting PAD.
Baiee et al. (Thu,) studied this question.