Synthesis of condensed chiral pyranopyran derivatives with antiproliferative activity using domino Knoevenagel-IMHDA sequences | Synapse
May 8, 2026Open Access
Synthesis of condensed chiral pyranopyran derivatives with antiproliferative activity using domino Knoevenagel-IMHDA sequences
Key Points
The research aims to develop chiral pyranopyran derivatives with antiproliferative activity through innovative synthetic methods.
Pentacyclic frameworks were synthesized using domino Knoevenagel-IMHDA sequences.
The reaction combines pyrano[4,3-b]pyran units with pyrone/pyridone and tetrahydroquinoline/chroman subunits.
The synthesized compounds exhibited significant antiproliferative activity against various cancer cell lines.
Targeted structures showed enhanced effectiveness compared to standard treatments.
Abstract
Pentacyclic frameworks containing a pyrano4,3- b pyran unit condensed with a pyrone/pyridone and a tetrahydroquinoline/chroman subunit were assembled in a domino Knoevenagel-hetero Diels–Alder reaction.