Abstract Background: Dental biofilm is the primary cause of the periodontal disease. Hence, control of dental biofilm is crucial for maintaining oral health. Objectives: This study aims to investigate the anti-inflammatory and anti-plaque effectiveness of an oral solution containing hyaluronic acid (HA) and hydrogen peroxide (H 2 O 2 ), as well as to evaluate any potential adverse effects and obtain feedback from the participants involved. Materials and Methods: The present investigation employed a short-term, parallel, and double-masked design. The present study comprised a study group of 54 students who exhibited gingivitis induced by biofilm and were ultimately included in the analysis. The individuals were allocated randomly into three groups: HA and H 2 O 2 (HA/H 2 O 2 ), n = 18; chlorhexidine (CHX) group, n = 18; and placebo group, n = 18. Clinical parameters (Gingival index and plaque index). Additionally, participants completed a visual analog scale-based assessment questionnaire. Results: There was a significant reduction in gingivitis in the HA/H 2 O 2 and CHX groups, but mouthwash with HA/H 2 O 2 had a greater effect size than CHX mouthwash. In addition, all interventions considerably decreased plaque outcomes, but CHX had a greater effect size than HA/H 2 O 2 mouthwash. The analysis of participant comments on the mouthwashes revealed that the HA/H 2 O 2 mouthwash was preferred over the CHX mouthwash. Conclusions: Mouthwashes containing (H 2 O 2 /HA) mouth rinse had significant anti-inflammatory properties and satisfactory levels of participant perception compared to the results associated with CHX use. However, it is less effective compared to CHX in reducing plaque. According to the findings of this research, mouthwashes containing (HA/H 2 O 2 ) might be utilized as an alternative to CHX.
Al-yasari et al. (Thu,) studied this question.