GLP-1 Receptor Agonist Drugs, Gastric Emptying, and Fatal Perioperative Pulmonary Aspiration: A Systematic Review and Meta-Analysis

Key Points

• This research aims to investigate the relationship between GLP-1 receptor agonist drugs and the risk of fatal perioperative pulmonary aspiration.
• Conducted a systematic review and meta-analysis of 63 studies involving 11,793 patients across 18 countries.
• Analyzed extracted data using R software including risk of bias assessments and interactive forest plots.
• Followed PRISMA 2020 guidelines for comprehensive data extraction and reporting.
• Identified a significant correlation between GLP-1 receptor agonist use and increased risk of pulmonary aspiration during surgical procedures.
• Extracted data included various aspiration event rates, showing a potential elevation in risk with these medications.
• Risk assessments indicated a need for further guidelines on managing GLP-1 receptor agonists in perioperative settings.