), a protective secretory protein, downregulated in PE offspring. Immunohistochemistry demonstrated increased epithelial Ltf expression from P7 to P21, which was impaired in PE offspring. Following enteritis induction, the PE offspring showed increased severity, which was markedly mitigated by prophylactic LTF supplementation. These findings highlight the importance of risk-based preventive strategies for postnatal intestinal disorders in infants exposed to placental insufficiency-induced intrauterine stress.
Ohtani et al. (Wed,) studied this question.