Abstract Background: Periodontitis is a chronic inflammatory disease affecting the supporting structures of teeth. Cytokines have a dynamic role in both starting and regulating the inflammatory process associated with periodontitis. A powerful anti-inflammatory cytokine called interleukin-13 has been found to inhibit the production of pro-inflammatory cytokine, prevents the creation of osteoclasts, and may prevent bone resorption in periodontitis. Objective: The scope of the current investigation was to discover the association of serum levels of T-helper-2 (IL-13) cytokine with periodontitis. Materials and Methods: The study involved 88 Iraqi participants who were categorized into two distinct groups: a periodontitis group (44 individuals) and a control group (44 subjects). Clinical periodontal parameters were measured, alongside the collection of venous blood samples from each participant, which were then analyzed to determine the levels of IL-13 serum. Results: The serum level of IL-13 was found to be nonsignificantly lower in the periodontitis group (2.78 ± 0.79 pg/mL) compared to the control group (3.22 ± 1.31 pg/mL). Additionally, no significant association was observed between the serum level of IL-13 and the clinical periodontal parameters. Conclusion: Even though a nonsignificant association was detected between IL-13 and periodontitis, IL-13 levels were reduced in periodontitis patients compared to healthy controls. Suggesting its role as an inhibitory factor in inflammation associated with periodontitis.
Fadhil et al. (Thu,) studied this question.