Intelligent Bio‐MOF Nanozymes With Dual Antibacterial and Antioxidant Capabilities Through pH‐Modulated Double Cascade Reactions for Anti‐Fibrosis

Key Points

• The aim is to develop bio-MOF nanozymes that exhibit both antibacterial and antioxidant effects to promote scarless healing.
• In vivo experiments were conducted using rat infected wound models.
• The study focused on the regulation of antibacterial and antioxidant mechanisms via pH modulation.
• Assessment of fibroblast proliferation and collagen deposition was performed to evaluate healing outcomes.
• Enhanced antibacterial efficacy was observed in treated wounds compared to controls.
• Inhibition of excessive fibroblast proliferation and reduced collagen deposition were reported, indicating improved healing.
• Scar area was significantly reduced, promoting scarless healing.