What question did this study set out to answer?

This study aims to compare the physical, mechanical, and biological properties of porcine urinary bladder acellular matrix with other collagen membranes from animal origins.

May 8, 2026Open Access

Comparison of physical, mechanical and biological properties of a porcine urinary bladder acellular matrix collagen membrane with six other collagen membranes of animal origin

Key Points

This study aims to compare the physical, mechanical, and biological properties of porcine urinary bladder acellular matrix with other collagen membranes from animal origins.
Included 70 membranes (n=10 per group) from porcine, equine, and bovine sources.
Analyzed surface morphology, hydrophilic properties, degradation ratios, thermal stability, tensile strength, and biological properties such as cell viability and osteopontin quantification.
Measured alkaline phosphatase activity and calcium deposition.
AUBM membranes exhibited surface morphology comparable to porcine pericardium, equine pericardium, equine Achilles tendon, and bovine Achilles tendon.
AUBM had a low degradation ratio and thermal stability similar to other membranes, and high elongation when wet.
Biological properties of AUBM membranes promoted osteogenesis effectively, similar to porcine peritoneum.

Abstract

Abstract Background The porcine acellular urinary bladder matrix (AUBM) is a three-dimensional scaffold rich in collagens type I, III, IV, and VI that could be used for guided bone regeneration (GBR). The objective of this study was to compare the physical, mechanical and biological properties of a AUBM with six other collagen membranes of porcine, equine and bovine origin. Methods Seventy membranes were included ( n = 10 per group). The properties of AUBM membrane were compared with the other animal collagen membranes available: porcine pericardium (PP), equine pericardium (EP), bovine pericaridium (BP), porcine peritoneum (PPE), equine Achilles tendon (EAT), bovine Achilles tendon (BAT). We analysed physical properties (surface morphology, hydrophilic property, degradation ratio and thermal stability), mechanical properties (tensile strength and dry and wet elongation), and biological properties (cell viability, quantification of type I collagen and osteopontin, Alkaline Phosphatase (ALP) activity and calcium deposition). Results AUBM membranes showed a surface morphology (in smooth and rough surfaces) very similar to those of PP, EP, EAT, and BAT. The most hydrophilic membrane was PPE. The AUBM membranes showed a low degradation ratio and thermal stability similar to the other membranes. AUBM membranes had a tensile strength (dry and wet) and elongation (dry) similar to the other membranes. Their elongation was much higher than the rest when wet. AUBM membrane showed good biological properties. Conclusions AUBM membrane showed physical and mechanical properties similar to the other six membranes. However, upon wetting they were the membranes with the highest elongation capacity and showed similar properties to PPE membranes in promoting osteogenesis. AUBM could be an ideal collagen source for the manufacture of membranes for GBR, but further clinical studies are needed.

Bookmark

View Full Paper

Cite This Study

Camacho-Alonso et al. (Wed,) studied this question.

synapsesocial.com/papers/69fd7fb8bfa21ec5bbf08499 https://doi.org/https://doi.org/10.1186/s12903-026-08397-1

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Bookmark

View Full Paper