Herein, we report a straightforward method for synthesizing 1,1-disubstituted cyclopropyl ketones via a palladium-catalyzed cross-coupling of cyclopropyl(phenyl)methanone with aryl bromides. This method provides robust access to highly valuable cyclopropane scaffolds. Furthermore, by simply modulating the solvent, base, and temperature, the protocol enables a one-pot, selective process involving C-C bond cleavage and ring-opening or aromatic recyclization. This strategy facilitates the divergent synthesis of either 2-arylacetophenones or 2-aryl-3,4-dihydronaphthalen-1(2
Chen et al. (Wed,) studied this question.