What question did this study set out to answer?

The aim is to develop a framework for quantitative imaging of metabolic reaction rates in vivo.

May 9, 2026

SQ-KFP: A Framework for Spatially Quantitative Metabolic Flux Analysis Enables Imaging the In Vivo Absolute Metabolic Enzymatic Reaction Rate

Key Points

The aim is to develop a framework for quantitative imaging of metabolic reaction rates in vivo.
Developed the SQ-KFP framework for spatially quantitative metabolic flux analysis.
Utilized various detection methods to validate the results.
Analyzed metabolic flux across different tissues and organisms.
Established that metabolite concentrations cannot replace direct measurements of reaction rates.
Provided quantitative imaging that offers insights into metabolic processes across various tissues.

Abstract

(validated by various detection methods). These results demonstrate that neither metabolite concentrations nor isotopic labeling values can substitute for reaction rates. Our method provides quantitative imaging of metabolic reaction rates and enables spatial flux analysis across diverse tissues and organisms.

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Cite This Study

Liu et al. (Thu,) studied this question.

synapsesocial.com/papers/69fecfe9b9154b0b82876ec2 https://doi.org/https://doi.org/10.1021/acs.analchem.6c00605

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