What question did this study set out to answer?

To explore how silica exposure influences steroid hyporesponsiveness via STING activation in lung inflammation models.

May 9, 2026Allergy0 citations

Silica Aggravates Steroid Hyporesponsiveness via STING Activation in House Dust Mite Lung Inflammation

BMBushra MdkhanaUniversity of Sharjah NSNarjes Saheb Sharif‐AskariUniversity of Sharjah MEMariam Wed EladhamUniversity of Sharjah

Key Points

To explore how silica exposure influences steroid hyporesponsiveness via STING activation in lung inflammation models.
Utilized mouse models to examine the effects of silica and house dust mite (HDM) on lung inflammation.
Analyzed small airway resistance and cytokine responses following treatments with dexamethasone and H-151.
Conducted qRT-PCR to assess gene expression related to inflammation.
Silica exposure significantly aggravated steroid hyporesponsiveness with increased small airway resistance.
Combination treatment with dexamethasone and H-151 effectively reduced lung inflammation and cytokine levels.
Silica-induced granulocytic infiltration was observed, indicating an enhanced inflammatory response.

Abstract

The data that supports the findings of this study are available in the Supporting Information of this article. Data S1: all70350-sup-0001-Supinfo.docx. Data S2: all70350-sup-0002-Supinfo2.pdf. Table S1: Demographic characteristics of the enrolled subjects. Table S2: List of mouse (m) primer sequences used in qRT-PCR. Figure S1: Silica-driven small airway resistance in HDM lung inflammation. Figure S2: Silica induces mixed granulocytic infiltration. Figure S3: Silica exposure without HDM induces steroid-responsive lung inflammation in vivo. Figure S4: Combination of dexamethasone and H-151 attenuates lung inflammation and cytokine responses in HDM/silica model. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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